![]() Simply put, cancer is the abnormal growth of cells. This study first provides alternative splicing analysis on transcription level of IGF2BP3 regulation, which laid the foundation for later research on IGF2BP3 critical functions.Ĭancer is a complex disease caused by the malfunction of the cells regulation which is led by genetic and epigenetic mutations ( Moore et al., 2018). IGF2BP3 regulated alternative splicing of multiple genes mainly clustered at response to hypoxia, negative regulation of transcription, and embryonic development. Overexpressed IGF2BP3 has broadly increased genes expression which involved in G-protein coupled receptor signaling pathway, positive regulation of cell proliferation, and signal transduction. We used iRIP-seq and RNA-seq to analyze the transcript regulation and alternative splicing on IGF2BP3 treated with overexpression cells and control. Here we report the post-transcript regulation of IGF2BP3, which belongs to the insulin-like growth factor 2 mRNA binding protein family. RNA binding proteins (RBPs) play a key role in genome regulation. Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.This article incorporates text from the United States National Library of Medicine, which is in the public domain.Huang Xueqing, Zhang Jun, Jiang Yueqiang, Liao Xin, Hu Liya, Fang Yuanyuan, Zhang Yuting, Zeng Hao, Wu Hua, Liu Jian and Yin Tiejun * "IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity". "Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium". "Norepinephrine transporter (NET), serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies". Bottalico B, Larsson I, Brodszki J, et al."Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2)". Gründemann D, Hahne C, Berkels R, Schömig E (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Strausberg RL, Feingold EA, Grouse LH, et al."Regulation of human organic cation transporter hOCT2 by PKA, PI3K, and calmodulin-dependent kinases". Cetinkaya I, Ciarimboli G, Yalçinkaya G, et al."Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function". Leabman MK, Huang CC, Kawamoto M, et al."cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney". "The human organic cation transporter (hOCT2) recognizes the degree of substrate ionization". "Regulation of BOB.1/OBF.1 stability by SIAH". "Properties and regulation of organic cation transport in freshly isolated human proximal tubules". Pietig G, Mehrens T, Hirsch JR, et al."Gene structures of the human non-neuronal monoamine transporters EMT and OCT2". "Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27". Verhaagh S, Schweifer N, Barlow DP, Zwart R (1999). ![]() "Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine". "Cloning and characterization of two human polyspecific organic cation transporters". Gorboulev V, Ulzheimer JC, Akhoundova A, et al."The octamer-binding proteins Oct-1 and Oct-2 repress the HIV long terminal repeat promoter and its transactivation by Tat". "Functional interaction between the HIV-1 Tat transactivator and the inhibitory domain of the Oct-2 cellular transcription factor". "In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor". "Functional roles for the TATA promoter and enhancers in basal and Tat-induced expression of the human immunodeficiency virus type 1 long terminal repeat".
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